Colitis Cystica Profunda: A Benign Deceiver in the Era of Advanced Imaging

Document Type : Review Article

Author

Department of Surgery, College of Medicine, Qassim University, KSA

10.30476/acrr.2026.110491.1282

Abstract

Colitis cystica profunda (CCP) is a rare, benign colorectal disorder characterized by mucin-filled cysts located
within the submucosa. Despite its non-neoplastic nature, CCP frequently mimics mucinous adenocarcinoma
clinically, endoscopically, radiologically, and histologically, posing a significant diagnostic challenge that can
lead to unnecessary radical surgery. This review synthesizes evidence from searches of PubMed, Embase, and
Google Scholar up to December 2025 to provide a contemporary overview of the etiopathogenesis, diagnostic
challenges, differential diagnosis, and management of CCP. Accurate diagnosis relies on demonstrating the
submucosal location of mucin-filled cysts and excluding invasive malignancy through a multimodal assessment.
Endoscopic ultrasonography and magnetic resonance imaging assist in defining lesion depth and maintaining
diagnostic confidence, while histopathological identification of a specialized lamina propria rim surrounding
displaced glands helps distinguish CCP from invasive adenocarcinoma. Current management emphasizes
correcting underlying mechanical factors, such as rectal prolapse and chronic straining, rather than routine
radical resection. Recognizing the characteristic features of CCP is essential to avoid misdiagnosis and to
support evidence-based, organ-preserving management.

Highlights

Sajad Ahmad Salati (Google Scholar)

Keywords


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