Perineal Ectopic Prostate Tissue: A Rare Case and Its Clinical Implications

Document Type : Case Report

Authors

1 Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Medical Imaging Research Center, Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

3 Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

10.30476/acrr.2025.104680.1229

Abstract

Ectopic prostate tissue is a rare condition characterized by the presence of prostate glands outside their typical
anatomical location, rather than the entire organ being displaced. While it is most commonly observed in the
lower male genitourinary system, it has also been reported in various other sites, including the pericolic fat, the
female genitourinary system, and even the spleen. The most common location is the urinary bladder trigone,
though it can also appear in the periurethral area or at the bladder neck. Here, we present a case involving
perineal ectopic prostate tissue that manifested as a significant mass. A 52-year-old man visited a colorectal
clinic due to a bulging, mass-like lesion in the perineal region. Perineal soft tissue sonography identified a
solid-cystic mass, while pelvic magnetic resonance imaging (MRI) revealed a large solid-cystic mass located
posterior to the sacrum, beneath the skin. Physical examination demonstrated a palpable, large perineal mass
extending from the inferior border of the scrotum to the anterolateral aspect of the anus. Laboratory data were
within normal limits. Both tru-cut biopsy and fine-needle aspiration (FNA) indicated a bloody, low-cellularity
specimen with no malignant cells. Subsequently, the entire mass was excised via a transperineal approach.
Pathological and immunohistochemical studies confirmed the presence of ectopic prostate tissue without any
signs of malignancy. Consequently, ectopic prostate tissue should be considered in the differential diagnosis of
any perineal mass, and surgical excision is recommended due to the potential risk of malignancy.

Keywords

References

1. Wader J, Kshirsagar A, Gajbi N,
Kumbhar S. Ectopic prostatic and
seminal vesicle tissue confusing as
metastatic adenocarcinoma. Online
Journal of Health and Allied Sciences.
2013;12(1 (8)).
2. Mikuz G. Ectopias of the kidney,
urinary tract organs, and male genitalia.
Der Pathologe. 2019;40(Suppl 1):1-8.
3. Kim JH, Jeen YM, Song YS. Ectopic
prostate tissue at the bladder dome
presenting as a bladder tumor. The
World Journal of Men’s Health.
2013;31(2):176-8.
4. Cimadamore A, Cheng L, Montironi
R. Ectopia of the Prostate.
Uropathology. 2020:87-8.
5. Bellezza G, Sidoni A, Cavaliere A.
Ectopic prostatic tissue in the bladder.
International journal of urology.
2005;12(12):1066-8.
6. Hanna B, McNaught A, Chung A,
Chalasani V. Ectopic prostatic tissue
in the perineum. BMJ Case Reports.
2020;13(11):e239378.
7. Jeong MJ. Ectopic prostate tissue
presenting as a giant pelvic mass
with seeding nodules. Radiology Case
Reports. 2022;17(6):2207-10.
8. Delladetsima J, Theodorou C, Dapolla
Y, Dimopoulos C. Prostatic-type
epithelium in urinary bladder clinical,
histologic, and immunohistochemical
study. Urology. 1990;36(5):445-8.
9. Dogra P, Ansari M, Khaitan A, Safaya
R, Rifat. Ectopic prostate: an unusual
bladder tumor. International urology
and nephrology. 2002;34:525-6.
10. Fulton RS, Rouse RV, Ranheim
EA. Ectopic prostate: case report
of a presacral mass presenting with
obstructive symptoms. Archives of
pathology & laboratory medicine.
2001;125(2):286-8.
11. Leifert S, Lurie A, Kellner J. Ectopic
prostatic tissue in urethra. Urology.
1985;26(5):509-10.
12. Gardner JM, Khurana H, Leach
FS, Ayala AG, Zhai J, Ro JY.
Adenocarcinoma in ectopic prostatic
tissue at dome of bladder: a case
report of a patient with urothelial
carcinoma of the bladder and
adenocarcinoma of the prostate.
Archives of pathology & laboratory
medicine. 2010;134(9):1271-5.
13. McCluggage WG, Ganesan R,
Hirschowitz L, Miller K, Rollason TP.
Ectopic prostatic tissue in the uterine
cervix and vagina: report of a series
with a detailed immunohistochemical
analysis. The American journal of
surgical pathology. 2006;30(2):209-15.
14. Wu X-L, Lin S, Zhao L-z, Wang
J-y, Dong P-d, Xia Y-z. Prostatic
tissue ectopia in the rectum. Chinese
medical journal. 2010;123(22):3372-4.
15. Nucci MR, Ferry JA, Young RH.
Ectopic prostatic tissue in the uterine
cervix: a report of four cases and
review of ectopic prostatic tissue.
The American journal of surgical
pathology. 2000;24(9):1224-30.
16. Backhouse A, Vasilaras A, Yung T,
Kench JG. Adenocarcinoma arising
within ectopic prostatic tissue in the
urinary bladder. Pathology-Journal of
the RCPA. 2014;46(7):655-7.
Iranian Journal of Colorectal Research
Volume 12, Issue 4
December 2024

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