Factors Affecting 5-Year Mortality of Colon Cancer in a Single Center

Document Type : Research/Original Article

Authors

1 Department of General Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Department of Pathology, Shahid Beheshti University of Medical sciences, Tehran, Iran

Abstract

Introduction: Colon cancer is considered one of the most lethal cancers globally, and various factors are thought to be associated with the survival rate of this disease. Identifying these factors is helpful in better management, efficient treatment, and increased patient survival. Therefore, this study aimed to investigate the relationship between demographic, clinical, and laboratory findings of colon cancer patients and their 5-year mortality rates.
Methods: A retrospective study was conducted on 54 patients diagnosed with colon cancer, and their demographic data, comorbidities, clinical and laboratory data were collected. The Spearman non-parametric statistical correlation test was utilized to analyze the relationships between these variables and the 5-year mortality of colon cancer. A P-value<0.05 was considered statistically significant. 
Results: The mean age of the patients was 60±12 years. A significant relationship was detected between carcinoembryonic antigen (CEA) level, recent significant weight loss, and pathological stage with the 5-year mortality of colon cancer. However, no statistically significant relationship was found between the 5-year mortality of colon cancer and comorbidities, age, gender, anatomical location of cancer, number of postoperative chemotherapy sessions, type of surgery, degree of tumor differentiation, lymphocyte count, serum albumin level, hemoglobin level, or need for emergency surgery.
Conclusion: CEA level, significant weight loss, and pathological stage of tumors may affect the 5-year mortality of colon cancer. 

Keywords

References

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Iranian Journal of Colorectal Research
Volume 11, Issue 4
December 2023
Pages 134-138

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