Iranian Journal of Colorectal Research

Iranian Journal of Colorectal Research

Potential Impact of Probiotics on Low Anterior Resection Syndrome: An Emerging Area of Research

Document Type : Editorial

Authors
Sara Shojaei-Zarghani 1
Ali Reza Safarpour 1
Alimohammad Bananzadeh 2
1 Colorectal Research Center, Shiraz University of Medical sciences, Shiraz, Iran
2 Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
10.30476/acrr.2023.101187.1201
Abstract
The worldwide age-standardized incidence and mortality rates of rectal cancer are estimated to be 7.6 and 3.3 per 100,000, respectively. 
Keywords
Low Anterior Resection Syndrome
Probiotics
Rectal Neoplasms
  1. Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. Available from: https://gco.iarc.fr/today/data/factsheets/cancers/9-Rectum-fact-sheet.pdf.
  2. Wang XT, Li DG, Li L, Kong FB, Pang LM, Mai W. Meta-analysis of oncological outcome after abdominoperineal resection or low anterior resection for lower rectal cancer. Pathology oncology research : POR. 2015;21(1):19-27.
  3. Croese AD, Lonie JM, Trollope AF, Vangaveti VN, Ho YH. A meta-analysis of the prevalence of Low Anterior Resection Syndrome and systematic review of risk factors. International journal of surgery (London, England). 2018;56:234-41.
  4. Pieniowski EHA, Palmer GJ, Juul T, Lagergren P, Johar A, Emmertsen KJ, et al. Low Anterior Resection Syndrome and Quality of Life After Sphincter-Sparing Rectal Cancer Surgery: A Long-term Longitudinal Follow-up. Diseases of the colon and rectum. 2019;62(1):14-20.
  5. Bryant CLC, Lunniss PJ, Knowles CH, Thaha MA, Chan CLH. Anterior resection syndrome. Lancet Oncol. 2012;13(9):e403-8.
  6. Emile SH, Garoufalia Z, Barsom S, Horesh N, Gefen R, Zhou P, et al. Systematic review and meta-analysis of randomized clinical trials on the treatment of low anterior resection syndrome. Surgery. 2023;173(6):1352-8.
  7. Afzaal M, Saeed F, Shah YA, Hussain M, Rabail R, Socol CT, et al. Human gut microbiota in health and disease: Unveiling the relationship. 2022;13.
  8. Ma W, Drew DA, Staller K. The Gut Microbiome and Colonic Motility Disorders: A Practical Framework for the Gastroenterologist. Current gastroenterology reports. 2022;24(10):115-26.
  9. Liu L, Wang A, Shi H, Tao H, Nahata MC. Efficacy and safety of probiotics and synbiotics for functional constipation in children: A systematic review and meta-analysis of randomized clinical trials. Clinical nutrition (Edinburgh, Scotland). 2023;42(10):1817-26.
  10. Stephens JH, Hewett PJ. Clinical trial assessing VSL#3 for the treatment of anterior resection syndrome. ANZ journal of surgery. 2012;82(6):420-7.
  11. Yoon BJ, Oh HK, Lee J, Cho JR, Kim MJ, Kim DW, et al. Effects of probiotics on bowel function restoration following ileostomy closure in rectal cancer patients: a randomized controlled trial. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 2021;23(4):901-10.
  12. Park IJ, Lee J-H, Kye B-H, Oh H-K, Cho YB, Kim Y-T, et al. Effects of probiotics on the symptoms and surgical outcomes after anterior resection of colon cancer (POSTCARE): a randomized, double-blind, placebo-controlled trial. Journal of clinical medicine. 2020;9(7):2181.
  13. Kim MJ, Park S, Park JW, Choi J, Kim HJ, Lim HK, et al. Gut microbiome associated with low anterior resection syndrome after rectal cancer surgery. Scientific reports. 2023;13(1):8578.
Iranian Journal of Colorectal Research
Volume 11, Issue 3
Summer 2023
Pages 91-92