Lichen planus associated with viral hepatitis C: clinical case.

Document Type : Case Report


1 Novosibirsk State Medical University, Novosibirsk, Russia.

2 Association of Obstetrician-Gynecologists and Dermatologists, Novosibirsk, Russia.

3 Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia.


Introduction. Lichen planus (LP) is an immune-mediated inflammatory disease that affects the skin, nails and mucous membranes. It`s etiology remains unknown, but there are several well-recognized trigger factors, including viral and bacterial antigens, as well as drugs and metals. The prevalence of hepatitis C virus (HCV) infection is the highest among patients with LP. It has been suggested that HCV may contribute to the development of LP, but the relationship between two of them is not fully understood. It is still controversial whether HCV leads to LP directly through replication within infected cells or indirectly through activation of immunological mechanisms. Molecular studies have identified HCV RNA in samples from patients with LP. An autoimmune theory has also been proposed, given that several studies have identified viral replication and activation of the immune response associated with the synthesis of autoantibodies.
Case presentation. The authors present a clinical case of a rare morphological form of LP against the background of HCV, which clearly illustrates the relationship between these diseases.
Conclusion. The study of the relationship between these diseases is necessary to understand the pathogenesis of LP, since this dermatosis is an urgent problem in modern dermatovenerology. Apparently, skin lesions are the result of an immune response to viral components, and not a direct result of HCV.


  1. Wagner G, Rose C, Sachse MM. Clinical variants of lichen planus. Journal der Deutschen Dermatologischen Gesellschaft= J ournal o f t he G erman S ociety of Dermatology : JDDG. 2013;11(4):309-19.
  2. Gorouhi F, Davari P, Fazel N. Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis. TheScientificWorldJournal. 2014;2014:742826.
  3. Mokni M, Rybojad M, Puppin D, Jr., Catala S, Venezia F, Djian R, et al. Lichen planus and hepatitis C virus. Journal of the American Academy of Dermatology. 1991;24(5 Pt 1):792.
  4. Gandolfo S, Carbone M, Carrozzo M, Gallo V. Oral lichen planus and hepatitis C virus (HCV) infection: is there a relationship? A report of 10 cases. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 1994;23(3):119-22.
  5. Le Cleach L, Chosidow O. Clinical practice. Lichen planus. The New England journal of medicine. 2012;366(8):723-32.
  6. Baccaglini L, Thongprasom K, Carrozzo M, Bigby M. Urban legends series: lichen planus. Oral diseases. 2013;19(2):128-43.
  7. Lazaro P, Olalquiaga J, Bartolomé J, Ortiz-Movilla N, Rodríguez-Iñigo E, Pardo M, et al. Detection of hepatitis C virus RNA and core protein in keratinocytes from patients with cutaneous lichen planus and chronic hepatitis C. The Journal of investigative dermatology. 2002;119(4):798-803.
  8. Lodi G, Carrozzo M, Hallett R, D'Amico E, Piattelli A, Teo CG, et al. HCV genotypes in Italian patients with HCV-related oral lichen planus. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 1997;26(8):381-4.
  9. Łapiński TW, Rogalska-Płońska M, Parfieniuk-Kowerda A, Świderska M, Flisiak R. The occurrence of autoantibodies in patients with chronic HCV infection, including patients dialyzed and after kidney transplantation. Clinical and experimental hepatology. 2016;2(4):161-6.
  10. Tampa M, Caruntu C, Mitran M, Mitran C, Sarbu I, Rusu LC, et al. Markers of Oral Lichen Planus Malignant Transformation. Disease markers. 2018;2018:1959506.
  11. Al-Mohaya MA, Al-Harthi F, Arfin M, Al-Asmari A. TNF-α, TNF-β and IL-10 gene polymorphism and association with oral lichen planus risk in Saudi patients. Journal of applied oral science : revista FOB. 2015;23(3):295-301.
  12. Farid C, Sheikh WE, Swelem R, El-Ghitany E. Frequency of FOXP3+ Regulatory T-cells in the Blood of Chronic Hepatitis C Patients with Immune Mediated Skin Manifestations; Relationship to Hepatic Condition and Viral Load. Clinical laborator y. 2016;62(12):2339-48.