Document Type : Research/Original Article
Authors
1
Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2
Department of Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
3
Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran
4
Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran
5
Department of Internal Medicine, Gastroenterology Division, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
6
Departments of Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran
Abstract
Background: Ulcerative colitis is acommontype of inflammatory bowel disease (IBD). The aim of the present study was to examine
the relationship between lipid profile, especially high-density lipoprotein (HDL), and malondialdehyde (MDA) level in patients with
ulcerative colitis.
Methods: In this study, 45 patients with ulcerative colitis were selected, 25 of whom were diagnosed with active disease and 20
were in clinical remission. Moreover, 45 healthy subjects were selected as the controls. The status of serum lipid profile and MDA
level were measured via precise photometric methods. The obtained data were analyzed, using independent t-test and correlation
coefficient test. P < 0.05 was considered statistically significant.
Results: The serum level of HDL-C decreased, while the serum level of MDA significantly increased in patients with ulcerative colitis
in comparison with the healthy controls (P < 0.05). No significant correlation was observed between theMDAlevel and triglyceride,
cholesterol, and LDL-C levels in patients with ulcerative colitis. However, a significant inverse correlation was observed between
HDL-C and MDA levels (r, -0.306; P < 0.05).
Conclusions: The inverse correlation between HDL-C andMDAlevels can be regarded as an indicator of the protective role of HDL-C
against lipid peroxidation in ulcerative colitis. In patients with ulcerative colitis, the serum level of HDL-C decreased in comparison
with healthy subjects. Therefore, it is necessary to determine the HDL-C level in patients with ulcerative colitis.
Keywords
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