Bactobilia Among Patients with Uncomplicated Cholelithiasis Undergoing Laparoscopic Cholecystectomy: The Risk Factors and Effects on Postoperative Infectious Complications

Ghahramani, Leila; Rezaeian Jahromi, Marzie; Pouladfar, Gholamreza; Bananzadeh, Alimohammad; Safarpour, Alireza; Hosseini, Seyed Vahid; Aminshahidi, Manli

Bactobilia Among Patients with Uncomplicated Cholelithiasis Undergoing Laparoscopic Cholecystectomy: The Risk Factors and Effects on Postoperative Infectious Complications

Document Type : Research/Original Article

Authors

Leila Ghahramani ¹

Marzie Rezaeian Jahromi ²

Gholamreza Pouladfar ³

Alimohammad Bananzadeh ¹

Alireza Safarpour ¹

Seyed Vahid Hosseini ¹

Manli Aminshahidi ³

¹ Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

² Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

³ Professor Alborzi Clinical Microbiology Research Center, Nemazee Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: Determining the rate of bactibilia among patients under going laparoscopic cholecystectomy (LC) and its correlations
with predisposing factors and postoperative infections, which help evaluate the need for prophylactic antibiotic.
Methods: In this prospective study, 85 consecutive patients with uncomplicated cholelithiasis who underwent LC were enrolled
from 2012 to 2013. Routine bile culture wasdoneat the time of LC. Patients were divided into 2 groups, 1 with negative bile cultureand
another with bactibilia. Demographic and laboratory data were compared. Patients were followedup10 days after their laparoscopy
and 1 month after discharge to monitor the presence of infection.
Results: A total of 7 cultures of bile were positive for bacteria (8.2 %). The patients’ age was the sole factor with a significant relationship
with the rate of bactobilia (P = 0.016). Within 10 days after surgery, fever and surgical site infection were detected in 10.6% of
patients, which was not significantly different in the 2 groups. There were no complications in the 30-day follow-up.
Conclusions: Detecting bactobilia with low frequency and the lack of correlation between bactobilia and postoperative infectious,
complications did not support prescribing prophylactic antibiotic in respective patients. The older age was the sole predisposing
factor for the development of bactobilia.

Keywords

Bactobilia

Laparoscopic Cholecystectomy

Gallstone

Postoperative Complication

Antibiotic Prophylaxis