The Correlation Between Single Nucleotide Polymorphism Patterns and Colorectal Cancer in the Iranian Population

Document Type : Research/Original Article

Authors

1 Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran

2 Gasteroenterohepatology Research Center, Nemazee Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran

3 Department of Biochemistry, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran

Abstract

Context: The incidence of colorectal cancer has significantly increased in Iran during the last decade. Accumulating evidence suggests
that there is a significant correlation between genetic variations such as polymorphisms and colorectal cancer. Therefore,
identification of critical polymorphisms related to colorectal cancer can contribute to find individuals at high risk of CRC.
Evidence Acquisition: The focus of this review was on published articles in English about the association between different single
nucleotide polymorphisms and colorectal cancer in the Iranian population. Evidences were gathered by searching online medical
databases including Google scholar, Pubmed, Scopus and Science Direct.
Conclusions: Various single nucleotide polymorphisms of critical genes indicated significant association with colorectal cancer in
the Iranian population. New polymorphism markers for high risk individuals have been recognized through further investigations
to reduce the incidence and mortality of colorectal cancer.

Keywords

Iranian Journal of Colorectal Research
Volume 4, Issue 3
September 2016

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