Document Type : Research/Original Article
Authors
1
Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IR Iran
2
Nutrition and Food Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
3
Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
4
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
5
Transplantation Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
6
Center for Academic and Health Policy, Tehran University of Medical Sciences, Tehran, IR Iran
7
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
Abstract
Background: Ulcerative colitis (UC) is a multi-factorial disease with unknown etiology and has many clinical manifestations.
Objectives: The current study aimed to evaluate the effects of sesame oil (SO) and grapeseed oil (GSO) on acetic acid-induced UC in
rats.
Materials and Methods: Eighty male rats were divided into eight groups as health control (HC1), received normal saline; HC2, received
SO; HC3, received GSO; negative control (NC), UC and normal saline; positive control (PC), UC and mesalamine; SO, UC and
SO; GSO, UC and GSO, and SO + GSO. The daily weight changes, serum levels of oxidative stress markers and lipid profile plus colon
macroscopic and microscopic histological changes were measured at the end of the seventh day.
Results: Significant differences were detected betweenHC1 and PC on the 3rd (P = 0.002), 4th (0.013) and 6th days (0.014) and between
HC1 and NC on the 4th day (0.027) in weight of rats. Use of GSO alone or in combination with SO decreased the extent of the changes
both in macroscopic and microscopic indices and also at the inflammation level. The most significant decrease in the MDA level
and the most obvious increase in the TAC belonged to the GSO group in comparison to the NC group. The lowest cholesterol (51.43
5.62 mg/dL) and HDL levels (29.29 6.24 mg/dL) were detected in response to SO consumption in comparison to NC group (P =
0.030 and P = 0.257, respectively).
Conclusions: GSO in combination with SO may be considered as the treatment of choice for UC based on antioxidant and
histopathological evaluations.
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