Department of Internal Medicine, Zaans Medisch Centrum, Zaandam, The Netherlands
Abstract
Background: Colorectal cancers (CRCs) often occur in octogenarians. However, data on treatment and survival are sparse. Objectives: Octogenarians were studied in order to gain data on treatment, outcomes, and survival related to CRC. Patients and Methods: All consecutive octogenarians with CRC in the period of 2002 - 2008 were included. An extensive review of hospital records was carried out. Patients were divided into two groups, as follows: group 1 included patients who were alive after five years of follow-up, while group 2 comprised patients who died within 5 years of their diagnosis. Cause of death was determined and classified as related to cancer, non-related, or because of treatment. Results: Onehundredandeleven octogenarians were diagnosed withCRC(82 colon cancersand29 rectal cancers). Patients in group 2 had a significantly higher disease stage compared with group 1 (P < 0.001). Patients in group 1 more often underwent surgery with curative intent (P< 0.0001). There was no difference in clinical presentation or localization of themalignancy. In group 1, 14 patients died more than 5 years after surgery. The cause of death was not related to cancer in 100% of cases. In group 2, 29 (46.0%) died as a direct consequence of CRC, 14 (22.2%) due to the treatment, and 20 (31.7%) died due to non-cancer-related causes. The overall 5- year survival rate was 40% in colon cancer patients and 51.7% in rectal cancer patients. The Charlson age co-morbidity scores were significantly lower in colon cancer patients in group 1 (P = 0.005). This was not the case in patients with rectal cancer. Conclusions: The co-morbidity score is important in survival after surgery. Forty-four percent of octogenarians with CRC died because of non-tumor-related disease or illness. Fit elderly people can benefit from standard therapy for CRC.
van Eeghen, E., Bakker, S., & Loffeld, R. (2016). Colorectal Cancer in Octogenarians: Results of Treatment, a Descriptive Clinical Study. Iranian Journal of Colorectal Research, 4(2), -.
MLA
Elmer van Eeghen; Sandra D. Bakker; Ruud JLF Loffeld. "Colorectal Cancer in Octogenarians: Results of Treatment, a Descriptive Clinical Study". Iranian Journal of Colorectal Research, 4, 2, 2016, -.
HARVARD
van Eeghen, E., Bakker, S., Loffeld, R. (2016). 'Colorectal Cancer in Octogenarians: Results of Treatment, a Descriptive Clinical Study', Iranian Journal of Colorectal Research, 4(2), pp. -.
VANCOUVER
van Eeghen, E., Bakker, S., Loffeld, R. Colorectal Cancer in Octogenarians: Results of Treatment, a Descriptive Clinical Study. Iranian Journal of Colorectal Research, 2016; 4(2): -.
)