Rectal Squamous Cell Carcinoma: A Case Report Of A Rare Histology

Document Type : Case Report

Authors

1 Malignant Disease Treatment Centre, Command Hospital (CC), Lucknow, India

2 Department of Pathology, Command Hospital (CC), Lucknow, India

Abstract

The rectum is an unusual and unlikely site for squamous carcinoma of the gastrointestinal tract. The clinical
presentation of this rare histology though, is similar to adenocarcinoma rectum. Being a rare clinical entity with
limited cases, the etiology, pathogenesis and optimal treatment regimen is still unclear. In this paper, we present
a case of a 55 years old man presenting with complaints of bleeding per rectum for previous six months. Imaging
revealed mass in rectum and the biopsy was suggestive of squamous cell carcinoma. He was treated with
abdominoperineal resection followed by adjuvant chemoradiotherapy.



The rectum is an unusual and unlikely site for squamous carcinoma of the gastrointestinal tract. The clinical
presentation of this rare histology though, is similar to adenocarcinoma rectum. Being a rare clinical entity with
limited cases, the etiology, pathogenesis and optimal treatment regimen is still unclear. In this paper, we present
a case of a 55 years old man presenting with complaints of bleeding per rectum for previous six months. Imaging
revealed mass in rectum and the biopsy was suggestive of squamous cell carcinoma. He was treated with
abdominoperineal resection followed by adjuvant chemoradiotherapy.

Keywords

References

1. Czito BWC. Colon cancer. In: Tepper GA, ed. Clinical radiation oncology. Edinburgh,
UK: Churchill Livingstone, 2007:1101–1111.
 
2. Dyson T, Draganov PV: Squamous cell cancer of the rectum. World J Gastroenterol
2009; 15:4380–4386.
 
3. Kang H, O’Connell JB, Leonardi MJ, et al: Rare tumors of the colon and rectum: a
national review. Int J Colorectal Dis 2007; 22:183–189.
 
4. Schmidtmann M: Zur Kenntnis seltener Krebsformen. Virchows Arch Pathol Anat
1919;226:100–118.
 
5. Williams GT, Blackshaw AJ, Morson BC. Squamous carcinoma of the colorectum and its genesis. J Pathol. 1979;129:139-147.
 
6. Kang H, O’Connell JB, Leonardi MJ, Maggard MA, McGory ML, Ko CY. Rare tumors
of the colon and rectum: a national review. Int J Colorectal Dis 2007; 22: 183-189.
 
7. Dyson T, Draganov PV: Squamous cell cancer of the rectum. World J Gastroenterol
2009;15:4380–4386.
 
8. Kong CS, Welton ML, Longacre TA: Role of human papillomavirus in squamous cell
metaplasia-dysplasia-carcinoma of the rectum. Am J Surg Pathol 2007;31:919–925.
 
9. Hicks JD, Cowling DC. Squamous-cell carcinoma of the ascending colon. J Pathol Bacteriol.
1955;70:205–212.
 
10. Jaworski RC, Biankin SA, Baird PJ. Squamous cell carcinoma in situ arising in inflammatory
cloacogenic polyps: report of two cases with PCR analysis for HPV DNA. Pathology. 2001;33:312–314.
 
11. Michelassi F, Mishlove LA, Stipa F, Block GE. Squamous-cell carcinoma of the colon. Experience at the University of Chicago, review of the literature, report of two cases. Dis Colon Rectum. 1988;31:228–235.
 
12. Nahas CS, Shia J, Joseph R, Schrag D, Minsky BD, Weiser MR, Guillem JG, Paty PB,
Klimstra DS, Tang LH, Wong WD, Temple LK. Squamous-cell carcinoma of the rectum:
a rare but curable tumor. Dis Colon Rectum 2007; 50: 1393-1400
 
13. Lafreniere R, Ketcham AS. Primary squamous carcinoma of the rectum. Report of a
case and review of the literature. Dis Colon Rectum 1985; 28: 967-972
 
14. Dewhurst C, Rosen MP, Blake MA, Baker ME, Cash BD, Fidler JL, Greene FL,
Hindman NM, Jones B, Katz DS, Lalani T, Miller FH, Small WC, Sudakoff GS,
Tulchinsky M, Yaghmai V, Yee J. ACR Appropriateness Criteria pretreatment staging of
colorectal cancer. J Am Coll Radiol 2012; 9: 775-781
 
15. Rasheed S, Yap T, Zia A, McDonald PJ, Glynne-Jones R. Chemo-radiotherapy: An
alternative to surgery for squamous cell carcinoma of the rectum-report of six patients
and literature review. Colorectal Dis 2009; 11(2): 191-7.
 
16. Clark J, Cleator S, Goldin R, Lowdell C, Darzi A, Ziprin P. Treatment of primary rectal
squamous cell carcinoma by primary chemoradiotherapy: Should surgery still be
considered a standard of care? Eur J Cancer 2008; 44(16): 2340-3.
Iranian Journal of Colorectal Research
Volume 7, Issue 3
September 2019
Pages 1-4

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