Clinical Pathological Analysis of Appendiceal Neoplasms From 4800 Appendectomy Specimens


1 Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran

2 Department of Pathology, Shiraz University of Medical Sciences, Shiraz, IR Iran

3 Department of Pathology, Urmia University of Medical Sciences, Urmia, IR Iran


Background Appendiceal Neoplasms are relatively uncommon. Although Carcinoid tumor is the most prevalent tumor of appendix, mucinous tumors and metastatic tumors can also be identified in appendectomy specimens after careful pathologic examination. Objectives The main goal of this study is the evaluation of appendectomy specimens for appendiceal neoplasms and subsequent subtyping of those tumors. Materials and Methods Retrospective assessment of 4800 appendectomy specimens, performed from 2010 to 2014, was done. The specimens were collected from Namazee and Faghihi hospitals, affiliated to Shiraz University of Medical Sciences. The clinical and histopathologic data were collected and analyzed by satisfactory statistical methods. Results The age of patients was 32 years with a male to female ratio of 3:1. The overall incidence of appendiceal neoplasms was 86 in 4800 specimens (1.8%). The most common neoplasm was carcinoid tumor. Others reported tumors were mucinous cyst adenoma, mucocele, mucinous adenocarcinoma, leukemic infiltration, and a case of appendiceal involvement by bladder transitional cell carcinoma. Conclusions Although appendiceal tumors are not as prevalent as colon cancer, careful examination of appendectomy specimens can identify neoplastic processes. Beyond carcinoid tumors and mucinous neoplasms, leukemia lymphoma and other metastatic tumors can involve the appendix.