Background Anal fissure is a painful tear or crack in the distal part of anal canal. It usually involves the epithelium, but in the long term it may extend to the whole anal mucosa. Platelet Lysate (PL) hydrogel is a hemoderivitive pharmaceutical formulation that contains plenty of growth factors. These growth factors can induce tissue regeneration and revascularization as well as fibroblast proliferation. Objectives This study aimed to evaluate the effectiveness of PL hydrogel in the treatment of the anal fissure or retardation of its development. Patients and Methods The patients with chronic and acute anal fissure were randomly divided into groups of A and B. Group A received PL hydrogel and Rectol, while group B received placebo and Rectol. Then, they were followed and evaluated for two weeks. Results Although it was anticipated that platelet growth factors would be effective in anal fissure healing process, no significant difference was observed between the control group and the case group after the treatment. Nevertheless, a significant difference was observed within the two groups after the treatment. Conclusions PL hydrogel does not seem to have beneficial effects compared to the placebo or Rectol on the healing of anal fissure.
Jamshidzadeh, A., Mardani, Z., Ghahramani, L., Mohammadi, S., Seyed Raoufi, S. M., Safarpour, A., Izadpanah, A., Hosseini, S. V., & Rahimi, M. (2014). Topical Platelet Lysate Hydrogel in Patients With Anal Fissure. Iranian Journal of Colorectal Research, 2(3), 0-0. doi: 10.17795/acr-24266
MLA
Akram Jamshidzadeh; Zeinab Mardani; Leila Ghahramani; Soleiman Mohammadi; Seyed Mojtaba Seyed Raoufi; Alireza Safarpour; Ahmad Izadpanah; Seyed Vahid Hosseini; Masoumeh Rahimi. "Topical Platelet Lysate Hydrogel in Patients With Anal Fissure", Iranian Journal of Colorectal Research, 2, 3, 2014, 0-0. doi: 10.17795/acr-24266
HARVARD
Jamshidzadeh, A., Mardani, Z., Ghahramani, L., Mohammadi, S., Seyed Raoufi, S. M., Safarpour, A., Izadpanah, A., Hosseini, S. V., Rahimi, M. (2014). 'Topical Platelet Lysate Hydrogel in Patients With Anal Fissure', Iranian Journal of Colorectal Research, 2(3), pp. 0-0. doi: 10.17795/acr-24266
VANCOUVER
Jamshidzadeh, A., Mardani, Z., Ghahramani, L., Mohammadi, S., Seyed Raoufi, S. M., Safarpour, A., Izadpanah, A., Hosseini, S. V., Rahimi, M. Topical Platelet Lysate Hydrogel in Patients With Anal Fissure. Iranian Journal of Colorectal Research, 2014; 2(3): 0-0. doi: 10.17795/acr-24266
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