Shiraz University of Medical SciencesIranian Journal of Colorectal Research2783-24303320150901Molecular Biomarkers of Colorectal Cancer: A Review of Published Articles From Iran004549310.17795/acr-30100ENBitaGeramizadehDepartment of Pathology, Transplant Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, IR IranJournal Article19700101Context Colorectal cancer is one of the most common cancers worldwide (the third most common cancer in the world) and is especially more common in Western countries; however, its incidence has been increased significantly during the last few years in Eastern countries such as Iran and considered as one of the five common cancers in this country. According to molecular pathways, numerous biomarkers have been identified for colorectal cancers which help patients’ management. Evidence aquisition In this study, we tried to review published articles about the molecular biomarkers of colorectal cancer from Iran. We searched medical databases such as google scholar, Scopus, PubMed, Magiran, SID and Iran Medex for keywords of “colon cancer, KRAS, BRAF, mismatch repair gene, Microsatellite instability, molecular genetics, molecular pathogenesis, biomarker and Iran” to find studies published about colorectal cancers from Iran regarding molecular biomarkers. Conclusion This study showed that molecular biomarkers in colorectal cancer of Iranian patients are not so different from Western population.https://colorectalresearch.sums.ac.ir/article_45493_0164fa998e4cce2578943d713289c81d.pdfShiraz University of Medical SciencesIranian Journal of Colorectal Research2783-24303320150901Comparison of Infection Incidence Between Appendectomy Skin Incisions Sutured by Nylon and Polyglactin (Vicryl)004549410.17795/acr-30179ENAlirezaGolchiniColorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR IranHabib AlahNikzad JamnaniColorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR IranSajjadAhmadiColorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR IranElhamKarimiDepartment of Surgery, Nursing Faculty, Shiraz University of Medical Sciences, Shiraz, IR IranSaeedehPourahmadColorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR IranAlirezaSafarpourColorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR IranZahraZabangirfardColorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR IranLeilaGhahramaniJournal Article19700101Background Suturing quality and reducing its complications and resulting infection have always been a major concern of surgeons. Many of them have prohibited applying polyfilament and absorbable suturing materials. Objectives In this study, we compared skin wound infection rate and other complications in two groups of post appendectomy patients whom were treated with two types of suturing materials - conventionally used Nylon and absorbable braided polyglactin (Vicryl) - and wound healing, existence of complication and recovery course of treated patients were surveyed. Patients and Methods A total of 130 patients who underwent appendectomy were divided into two groups of 645 members, each. Patients in group A had their incisions closed by separate sutures (mattress method) by vicryl, while patients in group B had their surgical incisions were closed in the same method, by nylon sutures. Any signs and symptoms of surgical site wound infection like inappropriate pain, redness, discharge, bulging, and unhealing wound were checked during hospital stay and on the 7th - 9th day postoperatively. Results The postsurgical complication and infections rates were similar between the two groups. Conclusions Vicryl sutures can safely be used for skin and subcutaneous wound suturing even when our surgery site is not ideally clean.https://colorectalresearch.sums.ac.ir/article_45494_7bc78397f80d05ef1120f03527461a32.pdfShiraz University of Medical SciencesIranian Journal of Colorectal Research2783-24303320150901Cryptosporidiosis and Colorectal Cancer004549510.17795/acr-31871ENSim SaiTinVirojWiwanitkitTropical Medicine Department, Hainan Medical University, Haikou, ChinaJournal Article19700101Background Suturing quality and reducing its complications and resulting infection have always been a major concern of surgeons. Many of them have prohibited applying polyfilament and absorbable suturing materials. Objectives In this study, we compared skin wound infection rate and other complications in two groups of post appendectomy patients whom were treated with two types of suturing materials - conventionally used Nylon and absorbable braided polyglactin (Vicryl) - and wound healing, existence of complication and recovery course of treated patients were surveyed. Patients and Methods A total of 130 patients who underwent appendectomy were divided into two groups of 645 members, each. Patients in group A had their incisions closed by separate sutures (mattress method) by vicryl, while patients in group B had their surgical incisions were closed in the same method, by nylon sutures. Any signs and symptoms of surgical site wound infection like inappropriate pain, redness, discharge, bulging, and unhealing wound were checked during hospital stay and on the 7th - 9th day postoperatively. Results The postsurgical complication and infections rates were similar between the two groups. Conclusions Vicryl sutures can safely be used for skin and subcutaneous wound suturing even when our surgery site is not ideally clean.https://colorectalresearch.sums.ac.ir/article_45495_0cdeab58aae9d391ce30d37132913a38.pdfShiraz University of Medical SciencesIranian Journal of Colorectal Research2783-24303320150901Conservative Management of Anterior Abdominal Stab Wounds004549610.17795/acr-32059ENSeyed VahidHosseiniDepartment of Surgery, Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR IranSeyed HesamaddinBanihashemiDepartment of Surgery, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, IR Iran0000-0002-0067-0659ShahlaFereidooniDepartment of Surgery, Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR IranJournal Article19700101Background Suturing quality and reducing its complications and resulting infection have always been a major concern of surgeons. Many of them have prohibited applying polyfilament and absorbable suturing materials. Objectives In this study, we compared skin wound infection rate and other complications in two groups of post appendectomy patients whom were treated with two types of suturing materials - conventionally used Nylon and absorbable braided polyglactin (Vicryl) - and wound healing, existence of complication and recovery course of treated patients were surveyed. Patients and Methods A total of 130 patients who underwent appendectomy were divided into two groups of 645 members, each. Patients in group A had their incisions closed by separate sutures (mattress method) by vicryl, while patients in group B had their surgical incisions were closed in the same method, by nylon sutures. Any signs and symptoms of surgical site wound infection like inappropriate pain, redness, discharge, bulging, and unhealing wound were checked during hospital stay and on the 7th - 9th day postoperatively. Results The postsurgical complication and infections rates were similar between the two groups. Conclusions Vicryl sutures can safely be used for skin and subcutaneous wound suturing even when our surgery site is not ideally clean.https://colorectalresearch.sums.ac.ir/article_45496_856824598d5513dd2f8e6815fcc3d9b7.pdfShiraz University of Medical SciencesIranian Journal of Colorectal Research2783-24303320150901Melilotus officinalis L. Protects Ulcerative Colitis in Rats004549710.17795/acr-32500ENHajarKhazraeiColorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR IranSeyed VahidHosseiniColorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran0000-0002-0067-0659FahimehHajhosseiniColorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR IranJournal Article19700101Background Suturing quality and reducing its complications and resulting infection have always been a major concern of surgeons. Many of them have prohibited applying polyfilament and absorbable suturing materials. Objectives In this study, we compared skin wound infection rate and other complications in two groups of post appendectomy patients whom were treated with two types of suturing materials - conventionally used Nylon and absorbable braided polyglactin (Vicryl) - and wound healing, existence of complication and recovery course of treated patients were surveyed. Patients and Methods A total of 130 patients who underwent appendectomy were divided into two groups of 645 members, each. Patients in group A had their incisions closed by separate sutures (mattress method) by vicryl, while patients in group B had their surgical incisions were closed in the same method, by nylon sutures. Any signs and symptoms of surgical site wound infection like inappropriate pain, redness, discharge, bulging, and unhealing wound were checked during hospital stay and on the 7th - 9th day postoperatively. Results The postsurgical complication and infections rates were similar between the two groups. Conclusions Vicryl sutures can safely be used for skin and subcutaneous wound suturing even when our surgery site is not ideally clean.https://colorectalresearch.sums.ac.ir/article_45497_1219f14dab88fef236d067e1af1423af.pdfShiraz University of Medical SciencesIranian Journal of Colorectal Research2783-24303320150901Perianal Paget’s Disease in a Forty-Five-Year-Old Man and Review of the Literature004549810.17795/acr-29093ENYavarShams HojjatiDepartment of Surgery, Mashhad University of Medical Sciences, Mashhad, IR IranAbbasAbdollahiGhodratollahMaddahEndoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, IR IranAsieh SadatFattahiEndoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, IR IranJournal Article19700101Introduction Extramammary Paget’s disease is a rare neoplasm of the skin that might develop in perianal region. Although different management options are available, wide local excision is still the method of choice. Case Presentation A 45-year-old man presented with perianal itchy lesions for one year with no response to local treatments. Perianal Paget’s disease was diagnosed by performing a surgical biopsy. Wide excision and flap reconstruction was done, while loop sigmoid colostomy was performed for fecal diversion. Re-excision of the involved margins was performed during the second operation. Conclusions A good outcome and no recurrence or complications was noticed in a follow-up period of 24 months. It is important to consider this uncommon disease as a probable diagnosis when evaluating a perianal lesion.https://colorectalresearch.sums.ac.ir/article_45498_f91421da8a4ba79cc7eef48e3b982e87.pdf