2024-03-29T05:04:18Z
https://colorectalresearch.sums.ac.ir/?_action=export&rf=summon&issue=5437
Iranian Journal of Colorectal Research
Iran. J. Colorectal. Res.
2018
6
1
Concepts of Hemorrhoids and Its Treatment in Avicenna’s Canon of Medicine
Mehdi
Tahamtan
Seyed Vahid
Hosseini
Seyyed Hamdollah
Mosavat
Alimohammad
Bananzadeh
Masoomeh
Rahimi
Hajar
Khazraei
Background: In this text, the important points of Avicenna’s Canon of Medicine on hemorrhoidal disease and its treatment havebeen introduced in light of colorectal surgery.Objectives: The aim of this study is to briefly explain the hemorrhoidal disease and its treatment through different sections ofAvicenna’s Canon of Medicine. A unique feature of the Canon is careful and precise observations and description of the disordersand diseases. However, the recommended treatment differs from which that used today except in a few diseases.Methods: The most detailed chapter regarding hemorrhoid in Canon of Avicenna, under the title of “Anal disease,” shows ratherprecise knowledge about anal disease and their surgical treatments in the 11th century.Results and Discussion: Avicenna explained in detail about anal diseases such as perianal abscess, fissure, rectal prolapse, andhemorrhoid in the 17th chapter of the 3rd volume of the Canon. Many herbs were used in anal disease by medieval physicians suchas Avicenna had antioxidant and anti-inflammatory effects. Thus, the knowledge of ancient physician can help us in developingnewtherapeutic methods.
Avicenna
Canon
Hemorrhoid
History of medicine
2018
03
01
https://colorectalresearch.sums.ac.ir/article_47164_69252a3ce791d4ca398676904a26e86e.pdf
Iranian Journal of Colorectal Research
Iran. J. Colorectal. Res.
2018
6
1
Inappropriate Total Oxidant/Antioxidant Status, Nitric Oxide Oxidation End Products and Trace Element Levels in Patients with Inflammatory Bowel Disease
Erfan
Mohammadi
Durdi
Qujeq
Hassan
Taheri
Karimollah
Hajian-Tilaki
Background: This study aimed at evaluating oxidant and antioxidant markers (including nitrite, nitrate, total antioxidant capacity(TAC), malondialdehyde (MDA), iron, selenium, glutathione peroxidase (GPx), and glutathione reductase (GR) in patients withinflammatory bowel disease (IBD) and compare them with healthy controls.Methods: Serum samples were obtained from 35 patients (19 ulcerative colitis (UC) and 16 Crohn’s disease (CD) in the active phaseof the disease) and 30 healthy controls. Serum levels of nitrite and nitrate, TAC, MDA, iron, selenium, glutathione peroxidase, andglutathione reductase were measured. The results were compared between the two groups using independent t-student test. ThePearson’s correlation coefficient (for continuous data) was performed using the SPSS software.Results: Serum levels of nitrite, nitrate, and MDA were significantly higher (P = 0.001) in patients with IBD, while the levels of TAC,trace elements, glutathione peroxidase (GPx), and Glutathione Reductase (GR) levels were lower (P < 0.05) in patients with IBD.However, when females were considered separately, Gpx and GR activities were not significantly different in those with and withoutIBD. The present results showed that nitrite, MDA, GPx, GR, and Se: MDA ratio had the strongest correlation with disease activityscore.Conclusions: There is an imbalance between oxidant and antioxidant properties in patients with IBD, which highlights the role ofoxidative stress in the pathogenesis of this disease.
Nitrites
Nitrates
Antioxidants
Malondialdehyde
Iron
Selenium
Glutathione Peroxidase
Glutathione Reductase
2018
03
01
https://colorectalresearch.sums.ac.ir/article_47165_745b6ceaab6fb0d41466596cb063b1df.pdf
Iranian Journal of Colorectal Research
Iran. J. Colorectal. Res.
2018
6
1
Comparative Analysis of Triple Hemostatic Open Hemorrhoidectomy Versus Traditional Open Hemorrhoidectomy
Muhammad
Shamim
Background: Traditional open hemorrhoidectomy is the most commonly performed operation for the third or fourth degree hemorrhoidsin the developing world, despite considerable postoperative pain and bleeding complications. This modification is anattempt to reduce these complications and compare the outcome of both methods.Methods: A prospective, comparative study was conducted in phase I, at Fatima hospital at Baqai Medical University, from March2009 to August 2011. It was followed by a descriptive case-series in phase II, conducted at different hospitals from September 2011to August 2017. The inclusion criteria were patients of both genders and all age groups, with third or fourth degree hemorrhoidsrequiring surgery. The exclusion criteria were patients in between blocks (operated by other surgeons), patients with complicatedhemorrhoids, closed hemorrhoidectomy cases, cases operated by residents, and cases lost to follow-up. In phase I, a total of 182patients were enrolled and randomly allocated to group A or B undergoing triple hemostatic hemorrhoidectomy and traditionalopen hemorrhoidectomy, respectively; 231 patients were included in phase II (group C) undergoing modified hemorrhoidectomy.The analyzed variables were operative blood loss, operative time, postoperative pain, hospital stay, time to pain-free defecation, andper-operative or postoperative complications.Results: There was significantly more operative blood loss in group B patients. Pain perception was significantly high in group Bpatients at eight and 24 hours, as well as eighth, 15th, and 30th days. Group B patients also had longer duration of operation andmore prolonged pain-free defecation. Both, intra-operative and post-operative complications were higher among the group B. Theoutcome of phase II (group C) was similar to those of group A.Conclusions: In a limited resource setting, triple hemostatic open hemorrhoidectomy offers potential advantages of less operativeblood loss, shorter duration of operation, shortened hospital stay, shorter time to pain free defecation, and less postoperative painand other complications.
Hemorrhoidectomy
Surgical Diathermy
Hemostatic Techniques
Hemorrhoids
2018
03
01
https://colorectalresearch.sums.ac.ir/article_47166_6660430da7b47203496fc26c39672b78.pdf
Iranian Journal of Colorectal Research
Iran. J. Colorectal. Res.
2018
6
1
Dynamics of Some Routine Immunological Parameters During Anti - TNF Therapy in Patients with Crohn’s Disease
Tsvetelina
Veselinova Velikova
Zoya
Angelova Spassova
Lyuben
Mitkov Milatchkov
Dobriana
Georgieva Panova
Ekaterina Ivanova
Ivanova - Todorova
Kalina Dinkova
Tumangelova - Yuzeir
Ekaterina Krasimirova
Kurteva
Dobroslav Stanimirov
Kyurkchiev
Siragan Arshavir
Deredjan
Rosen
Kirilov Nikolov
Iskra
Petrova Altankova
Lyudmila Mateva
Vladimirova
Background: Fecal and immunological biomarkers can be used to diagnose and manage patients with Crohn’s disease (CD). Anti -tumor necrosis factor (TNF) should be evaluated in addition to biomarkers to determine the response to therapy.Objectives: The current study aimed at following up fecal calprotectin (FC), perinuclear anti - neutrophil cytoplasmic antibodies(pANCA), anti - Saccharomyces cerevisiae antibodies (ASCA), and anti - nuclear antibodies (ANA) in patients with CD on anti-TNFtherapy.Methods: A total of 57 patients with CD and the mean age of 4015 years (ranged: 20 - 75) were monitored after initiation of anti- TNFa treatment. Stool samples were tested for FC (Alegria automated the enzyme - linked immunosorbent assay (ELISA) system),and serum samples for ANCA, ANA (indirect immunofluorescence - IIF), and ASCA (ELISA) in the beginning and after six months onimmunosuppressive therapy plus anti - TNFa agents.Results: Itwasobserved that all patients withCDhadsignificantly decreased FC levels after anti -TNFatherapy (963.97mg/kginitiallyvs. 268.42 mg/kg after treatment; P = 0.043). Moreover, in 75% of patients, FC levels dropped below the cutoff value of 50 mg/kg.Positive for ASCAIgA/IgG were 17/24 tested patients, butnodifferences were observed regarding the application of anti - TNFa therapy.However, the titers of pANCA decreased in four patients after anti - TNFa treatment.Conclusions: Initial and follow - up measurements of some immunological markers such as FC and pANCA could be of benefit forpatients with CD in anti - TNF therapy, whereas others such as ANA and ASCA were not useful to monitor the therapy.
TNFa Inhibitors
Immunological Biomarkers
Therapy Monitoring
2018
03
01
https://colorectalresearch.sums.ac.ir/article_47167_fe82d5e8d27380138a5ee05afed5d8a3.pdf