ORIGINAL_ARTICLE
Left-Sided Diverticulosis is a Risk Factor for Distal Colon Polyps
BACKGROUND AND AIMS Previous small to mid-sized studies have found an inconsistent relationship between diverticulosis and colon polyps. We assessed the odds of polyps in patients with left-sided diverticulosis (LDV) compared to patients without LDV, and if a predilection for polyps in the distal colon (DC) versus the proximal colon (PC) existed. METHODS In this case-control, retrospective study records of all patients in the Cleveland Clinic undergoing average-risk, screening colonoscopy between January 2011-August 2017 were identified. Baseline characteristics were described. Multivariate logistic regression analysis was performed to identify odds of polyps in PC and DC after adjusting for clinical and colonoscopic factors. RESULTS 50,703 patients (mean age=60 years; 48% male) were included; 38.9% of patients had LDV. Compared to patients without LDV, those with LDV more often had adenomas (33.2% vs 27.8%; p <0.001), hyperplastic polyps (HPs) (18.3% vs 16.2%; p <0.001), and sessile serrated polyps (SSPs) (4.8% vs 4.3%; P=0.011). LDV was associated with adenomas in the DC (OR, 1.59; 95%CI, 1.52, 1.67) more than the PC (OR, 1.15; 95%CI, 1.10, 1.21), with HPs equally in the PC (OR, 1.27; 95%CI, 1.20, 1.34) and DC (OR, 1.28; 95%CI, 1.19, 1.38), and with SSPs in the DC only (OR, 1.50; 95%CI, 1.34, 1.67). CONCLUSIONS LDV is associated with a significantly increased risk of adenomas, HPs, and SSPs, but the association was stronger for adenomas in the DC. Careful inspection of the DC should be encouraged in patients with LDV. More research is needed to understand this phenomenon.
https://colorectalresearch.sums.ac.ir/article_46438_99c38c079e7561a13b01e8a3557f361e.pdf
2020-03-01
1
8
10.30476/acrr.2020.46438
adenomas
colorectal cancer surveillance
sessile serrated polyps
sessile serrated polyps detection rate
adenoma detection rate
Shashank
Sarvepalli
ssarvepa@bcm.edu
1
Dept. of Gastroenterology & Hepatology, Baylor College of Medicine
AUTHOR
Pooja
Lal
puja.kanhyalal@gmail.com
2
Internal Medicine, Cleveland Clinic Foundation, OH. USA
LEAD_AUTHOR
Afrin
Kamal
kamala@stanford.edu
3
Division of Gastroenterology and Hepatology, Stanford University School of Medicine
AUTHOR
Ari
Garber
garbera2@ccf.org
4
Dept. of Gastroenterology and Hepatology, Cleveland Clinic Foundation
AUTHOR
John
McMichael
mcmichj2@ccf.org
5
Dept. of General Surgery, Cleveland Clinic Foundation
AUTHOR
Gareth
Morris-Stiff
morrisg4@ccf.org
6
Dept. of General Surgery, Cleveland Clinic Foundation
AUTHOR
John
Vargo
vargoj@ccf.org
7
Dept. of Gastroenterology and Hepatology, Cleveland Clinic Foundation
AUTHOR
Micheal
Rothberg
rothbem@ccf.org
8
Medicine Institute, Cleveland Clinic Foundation
AUTHOR
Maged
Rizk
rizkm@ccf.org
9
Dept. of Gastroenterology and Hepatology, Cleveland Clinic Foundation
AUTHOR
Carol
Burke
burkec1@ccf.org
10
Dept. of Gastroenterology and Hepatology, Cleveland Clinic Foundation
AUTHOR
1. Azzam N, Aljebreen AM, Alharbi O, Almadi MA. Prevalence and clinical features of colonic diverticulosis in a Middle Eastern population. World J Gastrointest Endosc 2013;5:391-7.
1
2. Wijarnpreecha K, Ahuja W, Chesdachai S, Thongprayoon C, Jaruvongvanich V, Cheungpasitporn W, et al. Obesity and the Risk of Colonic Diverticulosis: A Meta-analysis. Dis Colon Rectum 2018;61:476-483.
2
3. Tursi A. Dietary pattern and colonic diverticulosis. Curr Opin Clin Nutr Metab Care 2017;20:409-413.
3
4. Mehrzad R, Mishra S, Faller G, Memon B, Fiore J. Right-Sided Diverticulosis and Disparities from Left-Sided Diverticulosis in the Vietnamese Population Living in Boston, Mass., USA: A Retrospective Cohort Study. Med Princ Pract 2015;24:355-61.
4
5. DiSiena MS, Birk JW. Diverticular Disease: The Old, the New, and the Ever-Changing View. South Med J 2018;111:144-150.
5
6. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74-108.
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7. Pan P, Yu J, Wang LS. Colon Cancer: What We Eat. Surg Oncol Clin N Am 2018;27:243-267.
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8. Morini S, Hassan C, Zullo A, De Francesco V, Festa V, Barberani F et al. Diverticular disease as a risk factor for sigmoid colon adenomas. Dig Liver Dis 2002;34:635-9.
8
9. Wong ER, Idris F, Chong CF, Telisinghe PU, Tan J, Chong VH. Diverticular Disease and Colorectal Neoplasms: Association between Left Sided Diverticular Disease with Colorectal Cancers and Right Sided with Colonic Polyps. Asian Pac J Cancer Prev 2016;17:2401-5.
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10. Stefansson T, Ekbom A, Sparen P, Påhlman L. Increased risk of left sided colon cancer in patients with diverticular disease. Gut 1993;34:499-502.
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11. Morini S, de Angelis P, Manurita L, Colavolpe V. Association of colonic diverticula with adenomas and carcinomas. A colonoscopic experience. Dis Colon Rectum 1988;31:793-6.
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12. Gohil VB, Patrie JT, Shami VM, Sauer BG, Argo CK, Crowe SE, et al. Colonic diverticulosis is associated with an increased adenoma detection rate in patients undergoing first-time screening colonoscopy. J Interv Gastroenterol 2012;2:70-75.
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13. Muhammad A, Lamendola O, Daas A, Kumar A, Vidyarthi G. Association between colonic diverticulosis and prevalence of colorectal polyps. Int J Colorectal Dis 2014;29:947-51.
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14. Meurs-Szojda MM, Terhaar sive Droste JS, Kuik DJ, Mulder CJ, Felt-Bersma RJ. Diverticulosis and diverticulitis form no risk for polyps and colorectal neoplasia in 4,241 colonoscopies. Int J Colorectal Dis 2008;23:979-84.
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18. Ashktorab H, Panchal H, Shokrani B, Paydar M, Sanderson A, Lee EL, et al. Association between Diverticular Disease and Pre-Neoplastic Colorectal Lesions in an Urban African-American Population. Digestion 2015;92:60-5.
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19. Peery AF, Martin CF, Levinson SE, Sandler RS. Colonic Diverticula Are Not Associated With an Increased Risk of Colorectal Adenomas. Am J Gastroenterol 2015;110:1694-7.
19
20. Hong W, Dong L, Zippi M, Stock S, Geng W, Xu C et al. Colonic diverticulosis is not a risk factor for colonic adenoma. Ther Clin Risk Manag 2018;14:531-537.
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25. Morini S, Hassan C, Zullo A, De Francesco V, Burattini O, Margiotta M et al. Epithelial cell proliferation of the colonic mucosa in diverticular disease: a case-control study. Aliment Pharmacol Ther 2005;21:1385-90.
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26. Tursi A, Brandimarte G, Elisei W, Inchingolo CD, Aiello F. Epithelial cell proliferation of the colonic mucosa in different degrees of colonic diverticular disease. J Clin Gastroenterol 2006;40:306-11.
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29
ORIGINAL_ARTICLE
Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer
Abstract: 1. Context Endoplasmic reticulum stress (ER stess) is associated with endoplasmic reticulum perturbation homeostasis. Prolonged ER stress conditions may induce cell death. Unfolded protein response (UPR) attempts to restore normal cell conditions. 2. Evidence Acquisition There now exists an emergent body of evidence identifying the WNT signaling network as a regulator of cancer cell metabolism. Given that existing findings show that the WNT pathway and ER stress regulates changes in metabolic activities of cancer cells suggesting these signaling pathways represent critical nodes in the regulation of central metabolism in tumors. 3. Results Findings suggest that the molecular cross-talks between hypoxic ER stress, Wnt/βcatenin signaling, may represent an important mechanism that enables some tumor subtypes to survival and grow in hypoxic conditions. 4. Conclusions The present article disuses differential effects of the activation of the three arms of UPR, namely endoplasmic reticulum kinase (PERK), activation transcription factor -6 (ATF-6), and inositol –requiring enzyme (IRE-1) on cancer. This review also highlights regulators and downstream effectors of Wnt cascade and addresses the increasingly apparent crosstalk of Wnt with other tumorigenic signaling pathways.
https://colorectalresearch.sums.ac.ir/article_46538_1e80213e37224b3916d6264810d9b07f.pdf
2020-03-01
9
16
10.30476/acrr.2020.46538
Endoplasmic reticulum
Stress
cancer
UPR
Wnt
Morvarid
Siri
morvarid.siri@gmail.com
1
Department of biochemistry, Shiraz University of medical sciences, Shiraz, Iran
AUTHOR
Seyed Vahid
Hosseini
hoseiniv@sums.ac.ir
2
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Sanaz
Dastghaib
suny.respina@gmail.com
3
Department of biochemistry, Shiraz University of medical sciences, Shiraz, Iran
AUTHOR
Pooneh
Mokarram
mokaram2@gmail.com
4
Autophagy Research center, Shiraz University of Medical Sciences, shiraz, Iran.
LEAD_AUTHOR
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67
ORIGINAL_ARTICLE
Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease
Abstract Background: Zataria multiflora Boiss is a well-known medicinal plant and its’ essential oil (EO) is traditionally used for treatment of respiratory and digestive disorders and/or bacterial, viral, fungal, and parasitic infections. Objective: This study was undertaken to evaluate the effect of long-term consumption of Z. multiflora EO on hematological and biochemical parameters in patients infected with liver hydatid disease. Materials and Methods: Fifteen patients were administered orally with Z. multiflora EO (60 mg daily) for six months. Hematological and biochemical analysis were performed on the blood samples of patients before the start of treatment and after completion of the treatment course. In hematological analysis, WBC, RBC, Hb, hematocrit, MCV, MCH, MCHC and platelets were measured. In biochemical analysis, FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, K, Cl, AST, ALT, and ALK were assessed. Results: No apparent changes were observed in the values of hematological parameters of the patients after treatment. No significant changes also occurred in the values of FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, and K. The mean values of AST, ALT and ALK enzymes decreased significantly after treatment (P ˂ 0.05). No adverse clinical event was noticed in the patients during the course of study. Conclusions: Long-term consumption of Z. multiflora EO induced no adverse effect on the hematological and biochemical parameters of patients infected with liver hydatid disease. Since Z. multiflora EO reduced the level of liver transaminases (AST, ALT and ALK), this herbal product may be considered as a hepatoprotective agent in human beings.
https://colorectalresearch.sums.ac.ir/article_46473_6fedafc1d0ba4decb42d9375ed7f2a37.pdf
2020-03-01
17
22
10.30476/acrr.2020.46473
Zataria multiflora
Essential oil
Hematological parameters
Biochemical parameters
Clinical study
Arash
Jafari
arash.jafari87@gmaill.com
1
School of Veterinary Medicine, Shiraz University, Shiraz, Iran
AUTHOR
Mohammad
Moazeni
moazeni@shirazu.ac.ir
2
Department of Pathobilogy, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
LEAD_AUTHOR
Seyed Vahid
Hosseini
hoseiniv@sums.ac.ir
3
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Hajar
Khazraei
hajarkhazraei@gmail.com
4
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
LEAD_AUTHOR
Samane
Nematolahi
samane.nematolahi@yahoo.com
5
Department of biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Seyed Mohammad Kazem
Tadayon
imantadayon1353@gmail.com
6
Colorectal Research Center Shiraz University of Medical Sciences Shiraz Iran
AUTHOR
(1) Sajed H, Sahebkar A, Iranshahi M. Zataria multiflora Boiss. (Shirazi thyme)—An ancient condiment with modern pharmaceutical uses. J Ethnopharmacol. 2013; 145(13): 686−695.
1
(2) Khazdair MR, Ghorani V, Alavinezhad A, Boskabady MH. Pharmacological effects of Zataria multiflora Boiss L. and its constituents, focus on their anti-inflammatory, antioxidant and immunomodulatory effects. Fundam Clin Pharmacol. 2018; 32(1): 26-50.
2
(3) Mahboubi M. Therapeutic Potential of Zataria multiflora Boiss in Treatment of Irritable Bowel Syndrome (IBS). J Diet Supp. 2019; 16(1): 119-128.
3
(4) Mahboubi M, Ghazian Bidgoli F. Antistaphylococcal activity of Zataria multiflora essential oil and its synergy with vancomycin. Phytomedicine. 2010; 17(7): 548–450.
4
(5) Saei Dehkordi SS, Tajik H, Moradi M, Khalighi Sigaroodi F. Chemical composition of essential oils in Zataria multiflora Boiss. from different parts of Iran and their radical scavenging and antimicrobial activity. Food Chem Toxicol. 2010; 48(6): 1562–1567.
5
(6) Moazeni M, Larki S, Saharkhiz MJ, Oryana A, Ansary Lari M, Mootabi Alavia A. In Vivo study of the efficacy of the aromatic water of Zataria multiflora on hydatid cysts. Antimicrob Agents Chemother. 2014; 58(10): 6003–6008.
6
(7) Sadeghi H, Robati Z, Saharkhiz MJ. Variability in Zataria multiflora Bioss. essential oil of twelve populations from Fars province, Iran. Ind Crops Prod. 2015; 67: 221–226.
7
(8) Saedi Dezaki E, Mahmoudvand H, Sharififar F, Fallahi S, Monzote L, Ezatkhah F. Chemical composition along with antileishmanial and cytotoxic activity of Zataria multiflora. Pharm Biol. 2016; 54(5): 752–758.
8
(9) Mahmoudvand H, Mirbadie SR, Sadooghian S, Fasihi Harandi M, Jahanbakhsh S. Saedi Dezaki E. Chemical composition and scolicidal activity of Zataria multiflora Boiss essential oil. J Essent Oil Res. 2017; 29(1): 42–47.
9
(10) Ziaee E, Razmjooei M, Shad E, Eskandari MH. Antibacterial mechanisms of Zataria multiflora Boiss. Essential oil against Lactobacillus curvatus. LWT Food Sci Technol. 2018; 87: 406-412.
10
(11) Ramezani M, Hosseinzadeh H, Samizadeh, S. Antinociceptive effects of Zataria multiflora Boiss. fractions in mice. J Ethnopharmacol. 2004; 91(1): 167–170.
11
(12) Moradi M, Tajik H, Razavi Rohani SM, Mahmoudian A. Antioxidant and antimicrobial effects of zein edible film impregnated with Zataria multiflora Boiss. essential oil and monolaurin. LWT Food Sci Technol. 2016; 72: 37-43.
12
(13) Shokri H, Asadi F, Bahonar AR, Khosravi AR. The role of Zataria multiflora essence (Iranian herb) on innate immunity of animal model. Iran J Immunol. 2006; 3(4): 164-168.
13
(14) Khosravi AR, Franco M, Shokri H, Yahyaraeyat R. Evaluation of the effects of Zataria multiflora, Geranium pelargonium, myrrh and lemon essences on immune system function in experimental animals. J Vet Res. 2007; 62(4): 119–123.
14
(15) Kamrani YY, Amanlou M, Yazdanyar A, AdliMoghaddam A, Ebrahimi SN. Potential antidiabetic and anti-oxidant activity of essential oil of Zataria multiflora leaves. Planta Med. 2008; 74(9): PA172.
15
(16) Mandegary A, Sharififar F, Abdar M. Anticonvulsant effect of the essential oil and methanolic extracts of Zataria multiflora Boiss. Cent Nerv Syst Agents Med Chem. 2013;13(2): 93-97.
16
(17) Mahboubi M, Heidarytabar R, Mahdizadeh E. Antibacterial activity of Zataria multiflora essential oil and its main components against Pseudomonas aeruginosa. Herba Polonica. 2017; 63(3): 18-24.
17
(18) Moazeni M, Borji H, Saboor Darbandi M, Saharkhiz MJ. In vitro and in vivo antihydatid activity of a nano emulsion of Zataria multiflora essential oil. Res Vet Sci. 2017; 114: 308-312.
18
(19) Khosravi AR, Shokri H, Tootian Z, Alizadeh M, Yahyaraeyat R. Comparative efficacies of Zataria multiflora essential oil and itraconazole against disseminated Candida albicans infection in BALB/c mice. Braz J Microbiol. 2009; 40(3): 439–445.
19
(20) Jafari AA, Falah Tafti A, Hoseiny SM. Antifungal effect of Zataria multiflora essence on experimentally contaminated acryl resin plates vith Candida albicans. Iran Red Crescent Med J. 2015; 17(1): e16552.
20
(21) Emamjomeh L, Imani S, Talebi K, Moharramipour S, Larijani K. Chemical composition and insecticidal activity of essential oil of Zataria multiflora Boiss. (Lamiaceae) against Ephestia kuehniella (Lepidoptera: Pyralidae). Euro J Exp Biol. 2014; 4(3): 253–257.
21
(22) Majlessi N, Choopani S, Kamalinejad M, Azizi Z. Amelioration of Amyloid β ‐Induced Cognitive Deficits by Zataria multiflora Boiss. Essential Oil in a Rat Model of Alzheimer's Disease. CNS Neurosci Ther. 2012; 18(4): 295-301.
22
(23) Mansoori P, Hadjiakhondi A, Ghavami R, Shafiee A. Clinical evaluation of Zataria multiflora essential oil mouthwash in the management of recurrent aphthous stomatitis. Daru. 2002; 10(2): 74–77.
23
(24) Amanlou M, Beitollahi JM, Abdollahzadeh S, Tohidast-Ekrad Z. Miconazole gel compared with Zataria multiflora Boiss gel in the treatment of denture stomatitis. Phytother Res. 2006; 20(11): 966-969.
24
(25) Babaee N, Baradaran M, Mohamadi H, Nooribayat S. Therapeutic effects of Zataria multiflora essential oil on recurrent oral aphthous lesion. Dent Res J. 2015; 12(5): 456–460.
25
(26) Mahboubi M. The potency of Zataria multiflora Boiss in treatment of vaginal infections. Infectio. 2018; 22(2): 76-83.
26
(27) Jang ES, Jeong SH, Hwang SH, Kim HY, Ahn SY, Lee J, Lee SH, Park YS, Hwang JH, Kim JW, Kim N, Lee DH. Effects of coffee, smoking, and alcohol on liver function tests: a comprehensive cross-sectional study. BMC Gastroenterol. 2012; 12(1): 145- 156.
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(29) Atayi Z, Borji H, Moazeni M, Saboor Darbandi M, Heidarpoura M. Zataria multiflora would attenuate the hepatotoxicity of long-term albendazole treatment in mice with cystic echinococcosis. Parasitol Int. 2018; 67(2):184–187.
29
(30) Maggiore MA, Pensel PE, Denegri GM, Elissondo MC. Chemoprophylactic and therapeutic efficacy of thymol in murine cystic echinococcosis. Parasitol Int. 2015; 64(5): 435–440.
30
(31) Andre WP, Ribeiro WL, Cavalcante GS, Santos JM, Macedo IT, Paula HC, de Freitas RM, de Morais SM, Melo JV, Bevilaqua CM. Comparative efficacy and toxic effects of carvacryl acetate and carvacrol on sheep gastrointestinal nematodes and mice. Vet Parasitol. 2016; 218: 52–58.
31
(32) Fabbri J, Maggiore MA, Pensel PE, Denegri GM, Gende LB, Elissondo MC. In vitro and in vivo efficacy of carvacrol against Echinococcus granulosus. Acta Trop. 2016; 164: 272–279.
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(33) Saleem M, Nazli R, Afza N, Sami A, Ali MS. Biological significance of essential oil of Zataria multiflora Boiss. Nat Prod Res. 2004; 18(6): 493–497.
33
(34) Gholami Mahtaj L, Boskabady MH, Mohamadian Roshan N. The Effect of Zataria multiflora and its Constituent, Carvacrol, on Tracheal Responsiveness and Lung Pathology in Guinea Pig Model of COPD. Phytother Res. 2015; 29(5): 730 -736.
34
(35) Shokrzadeh M, Chabra A, Ahmadi A, Naghshvar F, Habibi E, Salehi F, Assadpour S. Hepatoprotective effects of Zataria multiflora ethanolic extract on liver toxicity induced by cyclophosphamide in mice. Drug Res. 2015; 65(4): 169–175.
35
ORIGINAL_ARTICLE
The effect of various surgical techniques in difficult cholecystectomy: A retrospective cohort study
Background: Success of laparoscopic cholecystectomy depends on multiple factors.Knowledge about altered anatomy, physiology and pathology of gall bladder, and thesurgeons experience in applying different surgical technique during difficult cholecystectomyare collectively important for a safe outcome.Methods: A total data of 875 patients who underwent cholecystectomy were analysed from June 2014 to May 2019. Study was mainly focused on looking for various intraoperative findings that could be the reason for conversion to open cholecystectomy in patients with difficult anatomy, physiology and pathology associated gall stone disease.Results: about 279/875 (31.9%) had difficult gall bladder with altered anatomy and pathology. Overall, conversion rate among difficult laparoscopic cholecystectomy was 62/279 (22.2%). 36/875 (2.4%) patients undergone subtotal cholecystectomy. 1/875 (0.1%)had common bile duct injury underwent repair. 54/875 (61.7%) had developed overall complications and 1/875 (0.1%) died due sepsis.Conclusion: High conversion rate and complications are seen in patients with contracted gallbladder and adhesions due to previous intervention. Conversion from laparoscopic cholecystectomy to open cholecystectomy is not a complication but continuum of treatment to reduce morbidity. Use of the critical view of safety technique very useful.
https://colorectalresearch.sums.ac.ir/article_46494_48f29bf4c8e36806c9c72d01146b8075.pdf
2020-03-01
23
28
10.30476/acrr.2020.46494
Laparoscopic Cholecystectomy
open
Surgery
Manjunath
Maruti Pol
manjunath.pol@gmail.com
1
All India Institute of Medical Sciences New Delhi
LEAD_AUTHOR
Mir IS, Mohsin M, Kirmani O, et al. Is intra-operative cholangiography necessary during laparoscopic cholecystectomy? A multicentre rural experience from a developing world country. World J Gastroenterol. 2007;13(33):4493-7
1
Sari YS, Tunali V, Tomaoglu K, et al. Can bile duct injuries be prevented? “A new technique in laparoscopic cholecystectomy.” BMC Surg. 2005;5:14
2
Tang B, Cuschieri A. Conversions during laparoscopic cholecystectomy: risk factors and effects on patient outcome. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2006; 10(7): 1081–91
3
Ibrahim S, Hean TK, Ho LS, Ravintharan T, Chye TN, Chee CH. Risk factors for conversion to open surgery in patients undergoing laparoscopic cholecystectomy. World J Surg. 2006;30(9):1698–704
4
Tayeb M, Raza SA, Khan MR, Azami R. Conversion from laparoscopic to open cholecystectomy: multivariate analysis of preoperative risk factors. J Postgrad Med. 2005; 51(1):17–20
5
Simopoulos C, Botaitis S, Polychronidis A, Tripsianis G, Karayiannakis AJ. Risk factors for conversion of laparoscopic cholecystectomy to open cholecystectomy. Surg Endosc. 2005;19(7):905–9
6
Boerma D, Rauwa EA, Keulemans YC, et al. Wait and see policy or laparoscopic cholecystectomy after endoscopic sphincterotomy for bile duct stones: a randomised trial. Lancet. 2002; 360(9335): 761-5
7
Sarli I, Iusco DR, Roncoroni L. Preoperative endoscopic sphincterotomy and laparoscopic cholecystectomy for the management of cholecystocholedocholithiasis: 10 year experience. World J Surg 2003: 27:180-186
8
Allen NL, Leeth RR, Finan KR et al. Outcomes of cholecytectomy after endoscopic sphincterotomy for choledocholithiasis. J Gastrointest Surg 2006; 10: 292-296
9
Erdal Birol Bostanei, Metin Ercan et al. Timing of elective laparoscopic cholecystectomy after endoscopic retrograde cholangiopancreaticography with shphncterotomy : a prospective observational study of 308 patients. Langenbecks Arch Surg 2010; 395: 661-666
10
Rosen M, Brody F, Ponsky J. Predictive factors for conversion of laparoscopic cholecystectomy. Am J Surg. 2002; 184(3): 254–8
11
Singh K, Ohri A. Laparoscopic cholecystectomy – is there a need to convert? J Minimal Access Surg. 2005; 1(2): 59–62
12
Karayiannakis AJ, Polychronidis A, Perente S, Botaitis S, Simopoulos C. Laparoscopic cholecystectomy in patients with previous upper or lower abdominal surgery. Surg Endosc. 2004; 18(1): 97–101
13
Lal P, Agarwal PN, Malik VK, Chakravarti AL. A difficult laparoscopic cholecystectomy that requires conversion to open procedure can be predicted by preoperative ultrasonography. JSLS. 2002; 6(1): 59–63
14
Nagral S. Anatomy relevant to cholecystectomy. J Minimal Access Surg. 2005; 1(2): 53–8
15
ORIGINAL_ARTICLE
Filling the gap between microscopic and automated analysis of the tumor-stroma ratio
Determining the tumor-stroma ratio (TSR) using a conventional microscope is an easy to apply and highly reproducible method. Due to digitalization in the pathology workflow, the demand for automated analysis of the TSR method is rising. However, the process of automation is rather time consuming and needs validation before implementation in daily practice. In addition, international studies ask for exchange of digital images instead of the actual slides. This calls for an alternative digital scoring method. This brief report describes the pitfalls of analyzing the TSR using digital images and proposes essential adaptations to create a standardized and reproducible scoring protocol. By using a circular annotation to mimic the microscopic method, these pitfalls can be avoided. Scoring the TSR digitally using a circular annotation does not take much additional effort compared to the microscopic method. When a fixed size of the annotation is saved, new cases can be scored in less than two minutes. With this brief report we propose an adjusted method for scoring the TSR on digital images to fill the gap between microscopically and automated scoring of the TSR. In addition, it opens the opportunity for application in daily diagnostics.
https://colorectalresearch.sums.ac.ir/article_46475_08600a973b1cd14a1714468dc0c473f3.pdf
2020-03-01
29
32
10.30476/acrr.2020.46475
Automation
digital analysis
microscopic analysis
tumor-stroma ratio
Gabi
Pelt
g.w.van_pelt@lumc.nl
1
Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
LEAD_AUTHOR
Rob
Tollenaar
r.a.e.m.tollenaar@lumc.nl
2
Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
AUTHOR
Wilma
Mesker
w.e.mesker@lumc.nl
3
Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
AUTHOR
1. van Pelt GW, Sandberg TP, Morreau H, Gelderblom H, van Krieken J, Tollenaar R, et al. The tumour-stroma ratio in colon cancer: the biological role and its prognostic impact. Histopathology 2018 Aug;73(2):197-206.
1
2. Litjens G, Sanchez CI, Timofeeva N, Hermsen M, Nagtegaal I, Kovacs I, et al. Deep learning as a tool for increased accuracy and efficiency of histopathological diagnosis. Sci Rep 2016 May 23;6(26286.
2
3. van Pelt GW, Kjaer-Frifeldt S, van Krieken J, Al Dieri R, Morreau H, Tollenaar R, et al. Scoring the tumor-stroma ratio in colon cancer: procedure and recommendations. Virchows Arch 2018 Oct;473(4):405-12.
3
4. Mesker WE, Junggeburt JM, Szuhai K, de Heer P, Morreau H, Tanke HJ, et al. The carcinoma-stromal ratio of colon carcinoma is an independent factor for survival compared to lymph node status and tumor stage. Cell Oncol 2007 29(5):387-98.
4
ORIGINAL_ARTICLE
Colonoscopy-Assisted Resolving of Intussusception in Children, a Report of 15 Cases
There are few reports on the therapeutic role of colonoscopy in correcting intussusception of childhood. In the present report, 15 children (14 boys and 1 girl) presented with acute intussusception and successfully treated by colonoscopy were presented. The patients were referred to the gastroenterology clinic of Ami-Al-Momenin Hospital, Zabol, Iran from 2015 to 2018. The mean age of the patients was 36.6±28.7 months. After stablishing the diagnosis, they underwent colonoscopic reduction of intussusception by an experienced gastroenterologist. Following 24 hours of the procedure, follow up sonography was performed. Overall, 6 recurrences were identified in 4 (26.7%) patients which were managed by a second colonoscopy. A second recurrence was detected in two patients who finally underwent surgical reduction. Regarding the role of colonoscopy in providing a visual and real-time setting, this can be used as either a primary option or an alternative to radiologic and surgical procedures of intussusception reduction in children.
https://colorectalresearch.sums.ac.ir/article_46564_64f43a75887faff8f424f5c4dd0b8a73.pdf
2020-03-01
33
36
10.30476/acrr.2020.46564
Intussusception
Endoscopy
Enema
children
Iraj
Shahramian
ir_buper@yahoo.com
1
Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran
LEAD_AUTHOR
Behnoush
Behi
behnoushb_md@yahoo.com
2
Faculty of Allied Medical Sciences, Zabol University of Medical Sciences, Zabol, Iran
AUTHOR
Mehrdad
Salahifar
mehsalah.md@gmail.com
3
Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran
AUTHOR
Ali
Mirabbasi
ali.mirabbasi176@gmail.com
4
Department of radiology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran
AUTHOR
1. Simon NM, Joseph J, Philip RR, Sukumaran TU, Philip R. Intussusception: Single Center Experience of 10 Years. Indian Pediatr 2019;56(1):29-32.
1
2. Liu N, Yen C, Huang T, Cui P, Tate JE, Jiang B, et al. Incidence and epidemiology of intussusception among children under 2years of age in Chenzhou and Kaifeng, China, 2009-2013. Vaccine 2018;36(51):7862-7.
2
3. Yu M, Fang Z, Shen J, Zhu X, Wang D, Shi Y. Double simultaneous intussusception caused by Meckel's diverticulum and intestinal duplication in a child. J Int Med Res 2018;46(8):3427-34.
3
4. Fiegel H, Gfroerer S, Rolle U. Systematic review shows that pathological lead points are important and frequent in intussusception and are not limited to infants. Acta Paediatr 2016;105(11):1275-9.
4
5. Gluckman S, Karpelowsky J, Webster AC, McGee RG. Management for intussusception in children. Cochrane Database Syst Rev 2017;6:Cd006476.
5
6. Waseem M, Rosenberg HK. Intussusception. Pediatric emergency care 2008;24(11):793-800.
6
7. Edwards EA, Pigg N, Courtier J, Zapala MA, MacKenzie JD, Phelps AS. Intussusception: past, present and future. Pediatr Radiol 2017;47(9):1101-8.
7
8. Ugwu B, Legbo J, Dakum N, Yiltok S, Mbah N, Uba F. Childhood intussusception: a 9-year review. Annals of tropical paediatrics 2000;20(2):131-5.
8
9. Blanch AJ, Perel SB, Acworth JP. Paediatric intussusception: epidemiology and outcome. Emergency Medicine Australasia 2007;19(1):45-50.
9
10. Reijnen J, Festen C, Joosten H, WIERINGEN Pv. Atypical characteristics of a group of children with intussusception. Acta Pædiatrica 1990;79(6‐7):675-9.
10
11. Wang N, Cui XY, Liu Y, Long J, Xu YH, Guo RX, et al. Adult intussusception: a retrospective review of 41 cases. World J Gastroenterol 2009;15(26):3303-8.
11
12. Lai WP, Yang YJ, Cheng CN, Chen JS. Clinico-pathological features of intussusception in children beyond five years old. Acta Paediatr Taiwan 2007;48(5):267-71.
12
13. Ishikawa E, Kudo M, Minami Y, Ueshima K, Kitai S, Ueda K. Cecal intussusception in an adult with Cronkhite-Canada syndrome relieved by colonoscopy. Intern Med 2010;49(12):1123-6.
13
14. Tafner E TP, Mittledorf C, Pinhata J, Silva AL, Pilli S, da Silva JG, Hassegawa RT, Maruta L, Christiano C, Andrada L. Potential of colonoscopy as a treatment for intussusception in children. Endoscopy international open 2017;5(11):E1116-8.
14
15. Ondhia MN, Al-Mutawa Y, Harave S, Losty PD. Intussusception: A 14-year experience at a UK tertiary referral centre. J Pediatr Surg 2019.
15
16. Hutchinson J. A Successful Case of Abdominal Section for Intussusception, with Remarks on this and other Methods of Treatment. Medico-chirurgical transactions 1874;57:31.
16
17. Hipsley P. Intussusception and its treatment by hydrostatic pressure: based on an analysis of one hundred consecutive cases so treated. Medical Journal of Australia 1926;2(7):201-6.
17
18. Yamada M, Yamada K, Fujinami H. Colonoscopic reduction of colo-colic intussusception in an adult with immunoglobulin A vasculitis (Henoch-Schonlein purpura). Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2016;28(1):101.
18
19. Hsu WH, Lu CY, Hu HM. Sigmoid colon cancer with intussusception reduced by colonoscopy. Gastrointest Endosc 2015;82(4):753.
19
20. Bhandarwar AH, Tayade MB, Kori CG, Borisa AD, Sameer V. Caeco-colic intussusception in an adult: a rare case report. Updates Surg 2012;64(4):319-22.
20
ORIGINAL_ARTICLE
Pearls in the appendix (Myxoglobulosis) : a case report
We report a rare variant of mucocele of the appendix. An elderly gentleman was admitted with symptoms and signs of acute appendicitis. He underwent laparoscopic converted open appendicectomy. On exploration there were pearls or fish egg like globular material along with jelly in and around the appendix. On examination of the specimen a differential diagnosis of hydatid cyst or pseudomyxoma was considered. On microscopic examination, the globules consisted of eosinophilic laminations of mucin surrounding an amorphous granular core. After histopathological examination, our case was diagnosed as myxoglobulosis of the appendix.Acute appendicitis is a common clinical problem and appendisectomy a regular surgery. The clinician should be aware of this entity of myxoglobulosis, to avoid confusion with pseudomyxoma or hydatid cyst. Presence of typical fish eggs or pearls like globular structures in and around the appendix is suggestive of myxoglobulosis. Appendisectomy is curative treatment for patients with myxoglobulosis of appendix and there are no reports of its recurrence.
https://colorectalresearch.sums.ac.ir/article_46611_e75cf68904a1b099ec02a4a1cc757f35.pdf
2020-03-01
37
39
10.30476/acrr.2020.46611
Gastrointestinal surgery
General Surgery
chronic abdominal pain
Acute Appendicitis
Vidyachandra
Gandhi
drgandhivv@gmail.com
1
Consultant
Department of Surgical Gastroenterology
Ruby Hall Clinic
Sasoon Road
Pune
Maharashtra
India
LEAD_AUTHOR
Neeraj
Rayate
rayatemuneera@gmail.com
2
Department of general surgery ruby hall clinic sasoon road pune - 400001 maharshtra pune
AUTHOR
Satish
Pattanshetti
drsatishpattan@gmail.com
3
Department of general surgery ruby hall clinic sasoon road pune maharashtra pune
AUTHOR
Pratik
Gautam
pratik89ind@gmail.com
4
Department of general surgery ruby hall clinic sasoon road pune maharashtra india
AUTHOR
1. Rangarajan M, Palanivelu C, Kavalakat AJ, Parthasarathi R. Laparoscopic appendectomy for mucocele of the appendix: Report of 8 cases. Indian J Gastroenterol. 2006;Sep-Oct 25(5):256–7.
1
2. Ruiz-Tovar J, Teruel DG, Castiñeiras VM, Dehesa AS, Quindós PL, Molina EM. Mucocele of the Appendix. World J Surg. 2007 Mar 7; 31(3):542–8.
2
3. Smeenk RM, van Velthuysen MLF, Verwaal VJ, Zoetmulder FAN. Appendiceal neoplasms and pseudomyxoma peritonei: A population based study. Eur J Surg Oncol. 2008 Feb; 34(2):196–201.
3
4. Gonzalez JE, Hann SE, Trujillo YP. Myxoglobulosis of the appendix. Am J Surg Pathol.1988 Dec; 12(12):962–6.
4
5. Viswanath YK, Griffiths CD, Shipsey D, Oriolowo A, Johnson SJ. Myxoglobulosis, a rare variant of appendiceal mucocele, occurring secondary to an occlusive membrane. J R Coll Surg Edinb. 1998 Jun; 43(3):204–6.
5
6. COLLINS DC. A study of 50,000 specimens of the human vermiform appendix. Surg Gynecol Obstet. 1955 Oct;101(4):437–45.
6
7. Padhy BP, Panda SK. Myxoglobulosis of Appendix A Rare Entiy. Indian J Surg. 2013 Jun 18; 75(S1):337–9.
7
8. Lubin J, Berle E. Myxoglobulosis of the appendix. Report of two cases. Arch Pathol. 1972 Dec; 94 (6):533–6.
8
9. Maheshgir S Gosavi. Myxoglobulosis of the Appendix: A Rare Cause of Pelvic Pain. Int J Case Rep Short Rev. 2018; 4 (1):1–2.
9
10. Paremala K, Radhika M, Thambiah L,. Myxoglobulosis of lower lip: Report of two cases. J Oral Maxillofac Pathol. 2011; 15 (2):232.
10
11. Krajinović M, Fajdiga I, Gale N. Laryngeal Myxoglobulosis: A Rare Histologic Variant of Mucocele. The First Reported Case. Head Neck Pathol. 2019 Jul 27 :19–21.
11
12. Alcalay J, Alkalay L, Lorent T. Myxoglobulosis of the appendix. Br J Radiol. 1985 Feb; 58(686):183–4.
12
13. Probstein JG, Lassar GN. Mucocele of the appendix, with myxoglobulosis. Ann Surg. 1948; 127:171–6
13
14. Aho AJ, Heinonen R, Lauren P. Benign and malignant mucocele of the appendix. Histological types and prognosis. Acta Chir Scand. 1973; 139 (4):392–400.
14
15. Huang HC, Liu TP, Jeng KS. Intussusception of mucocele of the appendix: a case report. Zhonghua Yi Xue Za Zhi (Taipei). 1994 Feb; 53 (2):120-3
15
16. Aroukatos P, Verras D, Vandoros GP, Repanti M. Myxoglobulosis of the Appendix: A Case associated with Ruptured Diverticulum. Case Rep Med. 2010; Sep 2010 :1–3.
16
17. Reynu R, Zairul M, Kosai NR, Levin KB, Das S. A rare presentation of caviar appendix in an Amyand’s hernia. Brunei Int Med J. 2015; 11(4):209–13.
17
18. Sashiyama H, Abe Y, Sasagawa S, Hanada H. Unusual Presentation of Appendiceal Myxoglobulosis as a Right Inguinal Hernia. J Am Coll Surg. 2009 Feb; 208(2):314–5.
18
19. Falah H H, Maafi AA, Chatrnour G, Jahromi S K , Ebrahimi H. Myxoglobulosis, a Rare Variant of Appendiceal Mucocele: Case Report and Review of the Literature. Thrita J Med Sci. 2012 Dec 15;1(4):155–8.
19
20. Kocak C, Zengin A, Girgin I, Kartufan FF, Metineren MH. Myxoglobulosis in the appendix. Turkish J Surg. 2017 Dec 12; 33 (4):308–10.
20
21. Rolón PA. Myxoglobulosis of the appendix. Int Surg. 1977; Jun- Jul 62 (6–7):355–6.
21
22. Isaacs KL, Warshauer DM. Mucocele of the appendix: computed tomographic, endoscopic, and pathologic correlation. Am J Gastroenterol. 1992 Jun; 87(6):787–9.
22
ORIGINAL_ARTICLE
Platelet-Rich Plasma in Sphincteroplasty
I review the interesting article “Effects of Platelet-Rich Plasma on Healing of Sphincteroplasty: An Experiment in Rabbit Model” (1)about application of Platelet-Rich Plasma in the anal sphincteroplasty While reviewing the article which proposed a novel idea for improving the outcome of sphincteroplasty three issues were questionable for me: The first issue is the site of sphincterotomy as it is mentioned located in posterior midline. It is known that the external anal sphincter is connected posteriorly to the anococcygeal ligament posteriorly (2) and division of sphincter in this point is not always associated with separation of sphincter and fecal incontinence. Animal experiments on the anal sphincter is different in the basis of sphincter function rather than an anatomical basis has a physiologic basis and if sphincterotomy is done in an animal the impaired function should be demonstrated(3) before further intervention. Due to small size of sphincter complex in the small animals it is sometimes hard to understand the exact territory of muscle.
https://colorectalresearch.sums.ac.ir/article_46537_a4abb4874f21dd5089075803fd5fe51f.pdf
2020-03-01
40
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10.30476/acrr.2020.46537
PRP
Rabbit
Sphincteroplasty
Mohammad
Rezazadehkermani
rezazadehkermani@yahoo.com
1
Colorectal Research Center, Shiraz University of Medical Sciences
LEAD_AUTHOR
1. Izadpanah A, Nikzadjamnani H, Safarpour AR, Izadpanah A, Tadayon SMK. Effects of Platelet-Rich Plasma on Healing of Sphincteroplasty: An Experiment in Rabbit Model. Ann Colorectal Res. 2019; 7(3):2-8.
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2. Corman ML, Bergamaschi RCM, Nicholls RJ, Fazio VW. CORMAN’S COLON and RECTAL SURGERY: LIPPINCOTT WILLIAMS & WILKINS; 2013.
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3. Aghaee-afshar M, Rezazadehkermani M, Asadi A, Malekpour-afshar R, Shahesmaeili A, Nematollahi-mahani SN. Potential of Human Umbilical Cord Matrix and Rabbit Bone Marrow–Derived Mesenchymal Stem Cells in Repair of Surgically Incised Rabbit External Anal Sphincter. Dis Colon Rectum. 2009;52(10):1753-61.
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4. Izadpanah A, Rezazadehkermani M, Ghaderi M, Rahimikazerooni S, Safarpour A, Homayounid K, et al. Using amniotic membrane for anal sphincter repair in animal model. j coloproctol. 2016;36(1):40-4
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